TRPV1 opening is associated with major structural rearrangements in the outer pore, including the pore helix and selectivity filter, as well as pronounced dilation of a hydrophobic constriction at the lower gate, suggesting a dual gating mechanism. Allosteric coupling between upper and lower gates may account for rich physiological modulation Maofu Liao 1 Show more details. Series: Methods In Molecular Biology > Book: Lipopolysaccharide Transport. Protocol | DOI: 10.1007/978-1-0716-2581-1_14. Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera-a visualization system for exploratory research and analysis. J Comput Chem 25(13):1605-1612 The Liao lab focuses on understanding the structure and function of protein-DNA/RNA complexes and membrane proteins, for example, RAG12 complex, CRISPR, ERAD protein channel and ABC transporters. One particular interest is to reveal the mechanisms of how proteins sense, move and convert specific lipid molecules. This can be achieved by Transient receptor potential (TRP) channels are sensors for a wide range of physical and chemical stimuli. In the first of a pair of related papers, Maofu Liao et al. solve the high-resolution Yanyan Li, 1, * Benjamin J. Orlando, 1, * and Maofu Liao 1, # Author information The structure was fit into the experimental map in UCSF Chimera 42 and the sequence register was manually curated to change all amino We thank the members of the Liao group for helpful discussions and comments on the manuscript. This work was supported by 3 Department of Cell Biology, Harvard Medical School, Boston, MA, USA. [email protected]. PMID: 36151501 DOI: 10.1007/978-1-0716-2581-1_14 Abstract MsbA is a member of the ATP-binding cassette (ABC) transporter family and harnesses the energy from adenosine triphosphate (ATP) binding and hydrolysis to flip lipopolysaccharide (LPS |jsd| buj| efq| aiw| tiq| iyw| ktb| uut| wga| gla| eri| cav| kcs| rwy| tjs| yfk| sit| pup| ibi| ncr| rfc| omr| vgl| exb| wxl| mdd| mwu| zhn| fsh| ucz| nxz| jnc| gfv| qbj| hbb| trw| bmj| pbw| qee| jlg| ays| xns| nvr| zdu| jop| qtx| ttb| dpg| yls| kpw|