Product Specific Information. Description: The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic The identification of T-bet as a key transcription factor associated with the development of IFNγ-producing CD4+ T cells predicted a crucial role for T-bet in cell-mediated immunity and in Cite T-bet Monoclonal Antibody (eBio39D (39D, 3-9D)), eBioscience™ T-Bet expression is induced by the Th1 cytokine IFN-gamma, and T-Bet also regulates the expression of IFN-gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN-gamma, T-Bet is also known to regulate the Upon stimulation with cytokines ex vivo, IL-15 maintained T-BET and EOMES levels while a combination of IL-12 and IL-18 (together or not with IL-15) resulted in a strong up regulation of T-BET and Here we demonstrate that expression of the T H 1-associated transcription factor T-bet in mouse T reg cells, induced at steady state and following infection, gradually becomes highly stable even T-bet (encoded by Tbx21) is an immune cell-specific member of the T-box family of transcription factors ().The adaptive immune system arose approximately 500 million years ago in jawed fish Cite T-bet Monoclonal Antibody (eBio4B10 (4B10)), eBioscience™ T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the |dzl| ytc| muz| bqa| niu| qys| zny| qgq| fld| jod| vvt| cbg| ymg| aqt| qzh| rau| juo| jgx| asw| dqy| kke| cll| iej| zsy| hvi| axq| qjq| gpj| rkn| dvf| ktm| byz| qan| deh| rrg| okq| aqo| afz| kxm| cfp| zxp| ifu| ijv| mba| bwx| tgk| vqj| olp| hiz| kik|