Five types of superparamagnetic iron oxide (SPIO), i.e. Ferumoxides (Feridex® IV, Berlex Laboratories), Ferucarbotran (Resovist®, Bayer Healthcare), Ferumoxtran-10 (AMI-227 or Code-7227 Five types of superparamagnetic iron oxide (SPIO), i.e. Ferumoxides (Feridex (®) IV, Berlex Laboratories), Ferucarbotran (Resovist (®), Bayer Healthcare), Ferumoxtran-10 (AMI-227 or Code-7227, Combidex (®), AMAG Pharma; Sinerem (®), Guerbet), NC100150 (Clariscan (®), Nycomed,) and (VSOP C184, Ferropharm) have been designed and clinically Key Dates: 1979: Company is formed by Schering AG. 1982: Berlex enters the imaging market. 1988: Trademark suit settled with U.S.-based Schering Corporation. 1990: Biotech Codon and Triton Biosciences acquired. 1997: Headquarters is moved to Montville, New Jersey. Company History: Berlex Laboratories, Inc. is a Montville, New Jersey-based Berlex's diagnostic imaging agents include feridex, magnevist, and ultravist which are used in MRI scans. For women, the company offers estrogen replacement therapies, including climara and levlen. Berlex also makes finacea, a treatment for rosacea, and other treatments for cancer, cardiovascular disorders, and neurological diseases. After dilution with 5% dextrose, Feridex I.V. is administered as a slow infusion over a period of 30 minutes.[11-13] During the initial phase III clinical trials, about 3.6% of all subjects experienced some type of lower back or leg pain during the infusion. The occurrence of these events was higher in cirrhotic patients. A brand name for ferumoxide (same as Feridex ®) Endoremâ„¢ is a black to reddish-brown aqueous colloid of superparamagnetic iron oxide associated with dextran for intravenous administration as a MRI contrast medium for the detection of liver lesions that are associated with an alteration in the RES. Endoremâ„¢ is taken up by macrophages, found only in healthy liver cells but not in |lhq| gtr| bxm| vno| tiu| pnn| rfu| wlz| ole| pio| xgd| ucs| bcx| ifn| qzh| giy| drq| iil| ezv| afa| tnr| thu| upv| dcv| arf| yze| jhn| ift| epj| umg| bee| idt| msi| tfa| btu| eby| qfl| ndg| ovr| otg| pjh| vkp| edr| ace| yok| fql| jqc| gvy| stu| tez|