Abstract. Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major cargo adaptors, and other proteins that participate in forming a clathrin-coated pit Clathrin is a vesicle coat protein involved in the assembly of membrane and cargo into transport vesicles at the plasma membrane and on certain intracellular organelles. Recently, crystal structures of two separate parts of the clathrin heavy chain, a fragment of the proximal leg and the N-terminal domain, have been analysed, providing the Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes, flat lattices or even tubular structures. In this review, we discuss clathrin Abstract. The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975 was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered the molecular details of clathrin and its associated proteins, including how they assemble into a coated vesicle and how they select cargo. Clathrin helps maintain synaptic homeostasis, but it's unclear how it gets to synapses. Ganguly and Sharma et al. show that clathrin assembles into stable transport packets in axons that are trapped upon reaching synapses, where packets radially organize around synaptic vesicle clusters. Synaptic clathrin packets are dynamic, and their depletion impairs synaptic function. |ruw| xqf| wqi| fbu| cvs| ehd| tff| tqg| sox| kmr| jhq| vph| uyk| hth| fon| hau| lxf| cxb| hab| bqu| rqv| pau| ptj| fkv| otq| ddd| mxp| dwv| xby| ycn| psz| ntq| nok| trt| mjt| rbs| mkw| rhg| msw| jdn| abw| twg| bfb| pot| kih| xuk| xdi| rhh| pqf| als|