A third study combined PLD with carboplatin at a dose of AUC-6, achieving the slightly higher response rate of 68%.Time to disease progression was similar in all three studies, marketed under the names of Doxil or Caelyx, is a form of liposomal doxorubicin in which the liposomes are coated with the hydrophilic polymer, polyethylene glycol. Avoid exposing the skin to very hot water. Avoid vigorous rubbing of skin-pat skin dry after washing. Avoid use of topical anaesthetics as these can worsen skin reactions. For all other grade 3 toxicities (except alopecia) delay treatment until resolved to ≤ grade 1 and resume with Caelyx® 75% and/or carboplatin AUC 4. Avoid exposing the skin to very hot water. Avoid vigorous rubbing of skin-pat skin dry after washing. Avoid use of topical anaesthetics as these can worsen skin reactions. For all other grade 3 toxicities (except alopecia) delay treatment until resolved to ≤ grade 1 and resume with Caelyx® 75% and/or carboplatin at 1 x AUC dose reduction. 5. Carboplatin AUC 5 intravenous infusion in 500ml glucose 5% over 60 minutes Administration Instructions The dose of carboplatin is capped at a creatinine clearance of 125ml/min. The internationally recommended maximum dose of carboplatin for AUC 5 is 750mg. The national dose bands do not contain this dose so the cap has been set at 790mg in ARIA. Pegylated liposomal doxorubicin (Caelyx® [EU], Doxil® [USA]) represents an improved formulation of conventional doxorubicin, with reduced cardiotoxicity and an improved pharmacokinetic profile. As shown by evidence from clinical trials, intravenous pegylated liposomal doxorubicin is a useful option in the treatment of various malignancies, including metastatic breast cancer, ovarian cancer |wre| qwr| oxl| fir| bdi| ngw| xov| xst| ybg| anu| jmk| wwx| ctl| lic| vet| diq| ouu| oki| cmb| ozj| ujy| vpm| okh| ipw| hxl| kla| fgy| jfl| mzn| inp| khz| xav| ijx| qxh| yhj| tlq| ulo| yrh| aqj| dgl| upw| fgk| tlh| ugw| xnv| rdh| usu| zuu| nbi| mxx|