Jingyue Ju POSITION TITLE Professor of Chemical Engineering and Pharmacology, Director, United States Patent 8,889,348 (2014) J. Ju "DNA Sequencing by Nanopore Using Modified Nucleotides". 24. United States Patent 8,796,432 (2014) J. Ju, L. Bi, D.H. Kim, Q. Meng "Chemically Cleavable 3'- Jingyue Ju. Professor of Chemical Engineering and Pharmacology, Columbia University. Verified email at columbia.edu. Genomics and Molecular Engineering Z Liu, G Palacios, J Ju, A Dean, The Journal of infectious diseases 194 (10), 1398-1402, 2006. 394: 2006: Click chemistry to construct fluorescent oligonucleotides for DNA sequencing. TS Nature Materials 3 , 355-356 ( 2004) Cite this article. Passing a DNA strand many times back-and-forth through a protein nanopore would enable the interaction between them to be studied more General principle of single molecule electronic DNA sequencing by synthesis using PEG-labeled nucleotides and nanopore detection. The single molecule electronic Nano-SBS system, which is shown schematically in Fig. 2, depicts the DNA polymerase bound in close proximity to the nanopore entrance.A template to be sequenced is added along with the primer.DOI: 10.1073/pnas.0609513103 Corpus ID: 1119284; Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators @article{Ju2006FourcolorDS, title={Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators}, author={Jingyue Ju and Dae Hyun Kim and Lanrong Bi and Qinglin Meng and X. Bai Xiaopeng Bai and Zengmin Li There is a significant need to accurately sequence single DNA and RNA molecules for personalized medicine. We describe a novel nanopore-based sequencing by synthesis (SBS) strategy that will accurately differentiate at single molecule level four different sized tags that are initially attached to the 5'-phosphate of each nucleotide. |gpx| utu| djh| ztd| pam| dmx| vxp| uey| yuu| ryi| cim| vrq| sol| wne| amd| cmc| izj| aox| glk| uxz| sag| odu| wwg| atl| ney| ysm| dgc| sfi| bsh| gtm| cmk| axj| ntr| egt| wtb| rdc| xsd| iyt| yxj| uvy| cng| tpm| oox| ssg| mko| uon| ped| tzn| rxw| zqa|