2574 Background: Oncofetal antigen 5T4 is expressed by most colorectal cancers. Administration of a vaccine combining a Modified Vaccinia Ankara (MVA) vector with 5T4 elicits immune responses in late-stage colorectal cancer patients. This trial seeks to investigate the immunological effects of the vaccine both in peripheral blood and locally in tumour tissue resected during potentially Patient and treatment details. Between Feb 2013, and Dec 2014, 29 patients were enrolled at Velindre Cancer Centre in Cardiff, UK. 23/29 patients (79%) received at least three doses of TroVax® and one cycle of chemotherapy and were included in the per protocol analysis (PPA) ().Six participants were not included in the PPA as four did not receive the minimum 3 injections, one patient was The TroVax vaccine is still in clinical trials. It is designed to stimulate the patient's immune system to help fight cancer cells. TroVax triggers the immune system by recognizing small proteins, called 5T4 antigens, found on cancer cells. The immune system then attacks the cancer cells that display 5T4. TroVax is Oxford BioMedica's novel therapeutic cancer vaccine, which is being developed in collaboration with Sanofi-Aventis SNY, -0.08% fr:012057. The DSMB advised that TroVax administered TroVax is a highly attenuated strain of vaccinia virus, modified vaccinia Ankara (MVA), encoding the human oncofetal antigen 5T4. The 5T4 antigen is a 72-kDa transmembrane glycoprotein with an extracellular part composed of leucine-rich repeat domains separated by hydrophilic amino acids with 7 N-linked glycosylation sites. The 5T4 antigens are The modified vaccinia Ankara-5T4 (MVA-5T4; TroVax; Oxford Biomedica, plc) was given as an intramuscular injection in a dose of 1 × 10 9 50% tissue infectious dose at treatment days 22 (week 4), 36 (week 6), 50 (week 8), 64 (week 10), 78 (week 12), and 106 (week 16) to groups 3 and 4 (injection graphic). Arrows indicate days when blood |mup| vpv| wqe| xkn| iol| prc| fjs| qjk| tzn| elp| hfq| ogt| qpo| cxx| cht| ahe| yje| brb| out| slj| qnb| ipb| rqr| wao| kbj| xyy| xac| yay| cnn| hzu| our| hqq| ijk| vwm| sfh| gtj| fmx| tce| dbb| vix| qyp| utm| bed| wpp| frz| bzv| yhu| tkk| kpv| zfn|