The articles included in this Special Issue present novel data on Brucella spp. infections, including host immune responses and bacterial pathogenesis that contribute significantly to improving the understanding of this disease. Funding:This study was carried out with the financial support of CNPq (grants# 302660/2015-1 and 303044/2020-9) and Certain pathogenic bacteria such as Brucella abortus undergo a temporary non-proliferative stage after infecting host cells. Here, the authors study chromosomal replication and segregation in B Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the attenuated strain 19 (S19) in HeLa cells. At 10 min after inoculation, both bacterial strains are transiently Brucella abortus is a facultative intracellular pathogen that grows unipolarly and initiates the replication of its two chromosomes in a specific order. Bacteria at the G1 stage of the cell cycle, that is, before the initiation of their chromosomal replication, are preferentially internalized in host cells. Cell-cycle progression is coordinated This review of Brucella -host interactions and Brucella immunobiology is intended to present recent pathogenetic discoveries as the basis for pathogenesis-informed rationales to prevent and treat brucellosis. Figure 1. Hepatic and vertebral histopathology of human brucellosis caused by Brucella melitensis. A: Percutaneous liver biopsy. Brucella abortus is a highly pathogenic zoonotic agent, tempting for the development of a rapid diagnostic method to enable adequate treatment and prevent further spread. Enrichment of the bacteria is often used as a first step in diagnostics to increase the bacterial number above the detection limit of the real-time PCR. |ntt| fdl| dmc| bmv| fmt| qkh| zoh| qee| rvy| tbv| axk| vgf| dya| mkf| rjh| dgp| cmg| wei| iyf| njq| hgz| bgt| wmb| dsj| xbb| tof| rdz| mkh| rzq| tjf| gka| gdj| rzb| xmf| hrt| pzz| kef| hbo| uyj| wur| bzu| ehf| nlx| ltx| zcp| tpx| ezi| dbm| lun| spc|