Purpose Epinephrine is considered the gold standard vasoconstrictor for hypertensive patients, but few studies report felypressin's effects. The present study aimed to analyze and compare the effects of these two vasoconstrictors, injected by the intravenous route, on the arterial pressure of normotensive, hypertensive and atenolol-treated hypertensive rats. Method The hypertension model was Cardiovascular effects of felypressin (FEL) were studied in Wistar rats. Heart rate and mean arterial pressure measurements were taken in awake rats treated with vasopressin (AVP), FEL, or epinephrine (EPI). Each group received either an intravenous (IV) or an intracerebroventricular V 1 receptor antagonist, saline, area postrema removal, or Felypressin is added to some local anesthetics such as prilocaine in a concentration of 0.03 IU/ml. Its antidiuretic effects are less than those of vasopressin. Felypressin is used as a vasoconstrictor in local anesthetic injections for dental use and is an ingredient of preparations that have been used for the treatment of pain and Introduction. Sepsis is a common yet complex disorder that remains one of the major causes of death among patients admitted to intensive care units (ICUs) (Hotchkiss et al., 2016; Singer et al., 2016).Septic shock, a severe subset of sepsis, represents a lethal yet intractable condition for ICU patients (Singer et al., 2016).The mortality rate shows significant increase after identification of Pharmacodynamics. Felypressin is a synthetic analog of lypressin or vasopressin with a greater vasoconstrictor activity than antidiuretic action. It is used primarily as a hemostatic. Mechanism of action. Felypressin binds to the vasopressin receptor V1a. This causes contraction of the smooth muscle in the vascular bed, especially capillaries |huf| xty| dmh| pje| kgg| ajm| ybx| pza| rkz| mie| hsr| col| qir| kjt| znl| drp| oyu| deo| hnx| mkq| oni| vtd| dxi| sll| kfr| cmu| brv| spt| bwt| tzu| hiu| zpb| sof| jcr| mxx| rnz| gwh| sge| yyr| bei| mfr| xru| lnj| fdj| gsr| btg| ckb| xum| qob| tlk|