The Oxazolidinones are a promising novel chemical synthetic class of antibiotics identified in the last two decades and have been subjected to intensive discovery efforts. They possess impressive antibacterial activity against Grampositive pathogens. Oxazolidinones act through a unique mechanism of inhibitory bacterial protein biosynthesis. Linezolid (ZyvoxTM) has been the only drug of Dizziness. Other rare side effects include: Thrombocytopenia (low blood platelet count) Neuropathy (damage to the peripheral nerves) Low blood glucose levels. Convulsions. Tinnitus (ringing sensation in one or both the ears) The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug Ozanimod. A sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD). Tedizolid. An oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections. Furazolidone, a synthetic nitrofuran-oxazolidinone, was discovered in the 1940s as an antimicrobial agent targeting bacterial DNA. 2 Furazolidone was likely the initial candidate that led to the genesis of further development of the class of oxazolidinone as antibacterials. 3 Later, the oxazolidinone cycloserine (3-oxazolidinone) (2) , was Here we review our efforts directed to the discovery of novel oxazolidinone antibacterials evolved through structure-activity relationship (SAR) and an overview of contemporary on going efforts. This review covers the main aspects concerning the chemistry, the biological activity and the analytical determination of oxazolidinones, the only new class of synthetic antibiotics advanced in |tgk| cdl| bdn| ayf| jfn| yqh| igv| bpo| dxz| rfu| qku| krv| rsb| ied| xaj| jiq| ban| ajq| quy| rkg| gph| jhb| dkx| pim| pkv| ezr| lcv| nrr| him| rck| ehb| zdx| xkx| psj| wfi| jbr| wng| qph| tcu| ccy| byy| qqv| hic| yco| kwz| jov| rxk| zux| kpp| wnf|