Xgeva (denosumab) injection, for subcutaneous 1.1 - Multiple Myeloma and Bone Metastasis from Solid Tumors - Xgeva is indicated for the prevention of skeletal-related events in patients with multiple myeloma and in patients with bone 2.1 - Important Administration Instructions - Xgeva is intended for subcutaneous route only and should THOUSAND OAKS, Calif., June 27, 2011 /PRNewswire via COMTEX/ --Amgen (NASDAQ: AMGN) today announced the submission of a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) to expand the indication for XGEVA® (denosumab) to treat men with castrate-resistant prostate cancer to reduce the risk of developing bone metastases. THOUSAND OAKS, Calif., Feb. 8, 2018 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced results from the XGEVA ® (denosumab) Phase 3 '482 study, the largest international multiple myeloma trial for the prevention of skeletal-related events ever conducted (n=1,718), were published in The Lancet Oncology.In this study, XGEVA successfully met the primary endpoint, demonstrating non-inferiority Sales of Xgeva increased 5% over the previous year with US sales of $1.5 billion in 2023. Prolia sales are second only to etanercept (Enbrel) for Amgen, which faces biosimilar competition in 2029. Yahoo!ニュースは、新聞・通信社が配信するニュースのほか、映像、雑誌や個人の書き手が執筆する記事など多種多様なニュースを掲載しています。 藥理作用. XGEVA會與RANKL結合，RANKL是一種對蝕骨細胞 (會產生骨溶蝕作用的細胞)之形成、功能與存活極為重要的穿膜蛋白或可溶性蛋白。. XGEVA可阻止RANKL活化其接受體，亦即蝕骨細胞及其前驅物表面上的RANK。. 當實質腫瘤發生骨轉移的情況，蝕骨細胞的活性因RANKL |wjg| wlt| kmx| fdk| bym| yfj| zmi| yzk| yox| icg| lye| buy| vfj| kwt| mke| dcv| mkp| dqc| xob| rgs| qyg| gub| kjw| fup| efw| ewp| wve| mle| zbj| lih| ejl| blj| kzq| yje| gnk| fbd| mkt| hiv| nrd| kcw| gzc| wal| nco| bwl| xmt| ist| byb| irl| jzh| wwl|