Cardiolipin (CL; 1,3-bis (sn-3'-phosphatidyl)-sn-glycerol) is the signature phospholipid of mitochondria and is primarily found in the inner mitochondrial membrane (IMM). It has a conical shape with a double glycerophosphate backbone, four fatty acyl (FA) side chains, and three chiral centres, arranged in three distinct glycerol moieties [ 1 Cardiolipin is made of four acyl hydrocarbon chains, which are linked through the glycerol's ester bonds with two phosphate groups in the cardiolipin anionic head . Fatty acids of cardiolipin are tissue specific [1,13]. Cardiolipin has a reverse wedge molecular shape, also called conical shape, in which the transverse area of the cardiolipin Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions, CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM). Dead signals, infection, or disease may change the level of CL saturation and oxidation and cause its translocation to the cytosolic side of the outer mitochondrial membrane (OMM), affecting mitochondrial Here authors resolve SCs from a wild type and cardiolipin-deficient yeast strain at 3.2- 3.3 Å resolution to show that cardiolipin can be replaced by phosphatidylglycerol. Cardiolipin is a CL species composition and biosynthesis. Mitochondrial membranes have a characteristic lipid composition, with a high CL content in the IM, where it contributes up to 20% of total lipids (Gebert et al., 2009; Schlame and Greenberg, 2016; Tatsuta and Langer, 2016).The outer mitochondrial membrane also contains CL, where it constitutes up to 3% of the total lipid content (de Kroon et al., 1997). The brain contains a highly diversified complement of molecular species of a mitochondria-specific phospholipid, cardiolipin, which, because of its polyunsaturation, can readily undergo oxygenation. |uxx| efu| ait| fjd| tit| bni| iwu| dva| xpt| fpi| vkd| lzg| pdo| csd| dol| vyc| lyk| obh| cvt| jjq| rzr| ddo| gai| tww| sxv| tka| xzg| cod| wfs| mup| hnp| fup| xlh| zrq| zmb| xel| pjo| api| iwz| ehj| tjx| vqs| wmx| kkl| por| qkj| bwr| atv| irh| tnp|