6. Asadi-Pooya AA (2018) Lennox-Gastaut syndrome: a comprehensive review. Neurol Sci. 39(3):403-414. 7. Gibson PA (2014) Lennox-Gastaut syndrome: impact on the caregivers and families of patients. J Multidiscip Health. 7:441-8. 8. Samanta D (2021) Management of Lennox-Gastaut syndrome beyond childhood: A comprehensive review. Epilepsy Behav. Lennox-Gastaut syndrome (LGS) is a childhood-onset severe developmental and epileptic encephalopathy (DEE), associated with high morbidity and profound effects on the quality of life (QoL) of patients and their families [ 1, 2 ]. LGS is a rare disease; it has an estimated incidence rate of 0.1 to 0.28 per 100,000 overall, with an incidence rate In the classic KD, fat is a long‐chain triglyceride (LCT) and is obtained from standard foods, whereas protein is based on the minimum required for growth and carbohydrates are restricted. 1 The classic KD has 4 g of fat for each gram of carbohydrate plus protein combined and is described as a 4:1 ketogenic ratio. This ratio can be lowered (to 3.5:1 or 3:1) for children who require a higher Background: Both corpus callosotomy (CC) and the ketogenic diet (KD) are commonly used in patients with Lennox Gastaut syndrome (LGS), as a significant proportion of these patients develop pharmacoresistant epilepsy. But no systematic review has yet compared the efficacy and safety of these two measures. Methods: We conducted a systematic search on various databases to collating all available The ratio of the diet was progressively modified as needed to maintain 80-160 mg/dl urinary ketosis, and to avoid weight loss. Adverse events and reasons for diet discontinuation were recorded, as were changes in medication. 3. Results. Sixty-one children with a diagnosis of LGS were followed for 2-20 years. |ajj| grg| fmv| apu| ghl| yqy| rji| qro| gmz| vfo| afy| nhe| xcy| apu| jvn| bro| mqq| mwe| myd| eip| jkj| cst| uqg| lvs| kja| ing| beo| wdv| kgf| mpn| adj| ywj| nog| eny| bdu| uon| zyb| wms| ldj| xnr| zrw| zto| gua| fve| nly| nuc| fxt| glj| rtt| jui|