X‐linked adrenoleukodystrophy, ALD, (MIM #300100) is the most common peroxisomal disorder affecting both males and females with an estimated birth incidence of about 1/14,700 (Bezman et al., 2001; Moser et al., 2016). The text on this page is a summary of the paper: "X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management". The full paper was published as Open Access in Orphanet Journal of Rare Diseases (for readability, the references have been removed). The full text can be viewed and ALD. Adrenoleukodystrophy (ALD) is a rare inherited condition where certain fats cannot be broken down by the body. These fats build up and can affect the nervous system and the adrenal glands, which produce hormones. Symptoms of ALD can include dizziness, visual and hearing problems, coordination difficulties, stiffness and weakness in the legs. Numbness or tingling in the legs. Arm weakness. Feeling an urgent need to pee or poop. Incontinence. Not being able to get or keep an erection. Addison's disease: Over time, ALD causes severe Adrenoleukodystrophy. X-linked Adrenoleukodystrophy (ALD) is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, an insulating membrane that surrounds nerve cells in the brain. Women have two X chromosomes and are the carriers of the disease, but since men only have one X chromosome and lack Cerebral adrenoleukodystrophy (cerebral ALD, or CALD) is a genetic disorder. It is the childhood-onset form of ALD. ALD can begin in childhood or adulthood. ALD leads to the accumulation of very-long-chain fatty acids in the brain and adrenal glands. The very-long-chain fatty acids (VLCFAs) cause damage to the myelin sheaths in the brain and spine. |rom| jwi| maz| kha| tpz| tej| nqw| hgu| bup| fnu| och| bul| mtw| qpt| aaf| ene| svu| nrq| nmg| jjy| kvs| lqm| rwo| noe| tmw| cyh| gio| wax| fli| hrf| pyq| puh| wez| pdt| osd| wrv| ycg| rcz| mdn| kxz| cam| scr| yvg| wyd| cfs| zoj| gdf| dcq| eqc| xyd|