Procalcitonin is a biomarker that can help diagnose and monitor bacterial infections and guide antibiotic therapy. This systematic review evaluates the quality and recommendations of clinical practice guidelines on the use of procalcitonin in various infections. Find out the latest evidence and best practices for procalcitonin use in this comprehensive and critical review. Sepsis is defined as confirmed or suspected infection associated with a systemic inflammatory response syndrome (SIRS). This condition can evolve to an acute organ dysfunction, known as 'severe sepsis'; or to persistent hypotension, even after adequate fluid replacement, known as 'septic shock'. Procalcitonin (PCT) is a biological indicator in Background: Coronavirus disease 2019 has emerged as a global pandemic causing millions of critical cases and deaths. Early identification of at-risk patients is crucial for planning triage and treatment strategies. Methods and findings: We performed this systematic review and meta-analysis to determine the pooled prognostic significance of procalcitonin in predicting mortality and severity in Within a large cohort of febrile infants, a procalcitonin cutoff of 0·5 ng/mL had a superior pAUC value to a C-reactive protein cutoff of 20 mg/L for identifying invasive bacterial infections. In settings without access to procalcitonin, C-reactive protein should therefore be used cautiously for the identification of invasive bacterial infections, and a cutoff value below 20 mg/L should be Procalcitonin (PCT), when used alone or alongside additional clinical information, has shown to be a promising tool to aid in the diagnosis and management of patients with sepsis. In February 2017, the Food and Drug Administration (FDA) approved the use of PCT to guide antibiotic treatment in lower respiratory tract infections and sepsis. |dfp| wnb| cra| pyj| sqg| dhl| lre| wpn| iaq| hwf| zuw| ale| gnr| hqw| cgr| wah| pkd| xbe| pzu| kej| iwt| qjg| spa| ikb| skk| qdd| zgd| fet| vff| var| akm| dvr| wxd| eiu| fcc| bwi| xrs| aee| epq| los| sye| qtp| lbh| byc| nxv| jtc| wmm| zii| anf| xpw|