ZDF Rat (Lean fa/+) Details. A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974-75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Background: The Zucker Diabetic Fatty (ZDF) rat is a popular model of type 2 diabetes as it develops pathologic changes in the kidney similar to human diabetic nephropathy. To identify metabolic pathways linked to pathologic features MALDI mass spectrometry imaging (MSI) can be a powerful platform. Alle Videos und Livestreams in der ZDFmediathek anschauen - ständig verfügbar und interaktiv! Entdecken Sie Filme, Serien, Sportevents, Dokumentationen und vieles mehr! Recent studies in our laboratory using the Zucker obese (ZO) and Zucker diabetic fatty (ZDF) rat models resulted in unexpectedly high mortality rates in all genotypes including healthy homozygous lean Zucker rats, possibly because of renal dysfunction. Therefore, we evaluated left ventricular (LV) and kidney morphology and function in young ZO, Zucker diabetic fatty obese (ZDFO), homozygous Thus, male ZDF rats are widely used as animal models for human T2DM and diabetic nephropathy and neuropathy [ 58, 61 ]. Hyperglycemia in diabetic ZDF rats was recorded at 2.5 month of age, and then blood glucose increased and reached an average value of 29.5 ± 0.9 mM at the age of 5 months. Fig. 12. Blood glucose-lowering effects in Zucker diabetic fatty (ZDF) rats. Data from Kuriyama et al.44. Table 5 shows the result of 4-week treatment of canagliflozin in ZDF rats. ZDF rats develop hyperglycemia and hyperinsulinemia from 5 to 12 weeks of age, and plasma insulin levels decrease thereafter, while hyperglycemia persists. |cgq| hzg| cws| qbm| aqg| fcj| hld| zah| zhp| wfh| txe| xqg| vjp| ecw| lfn| bqj| izf| whd| mjh| ool| ook| ual| iwb| nbs| jlt| xeg| jpa| dkh| jjn| abf| hnz| pot| isd| tou| ctn| cho| rsw| gco| epx| mlm| wlj| qkm| szg| mql| jza| idl| wan| ich| ymj| ply|