Duane syndrome is a type of strabismus, an eye misalignment that's congenital (something you're born with). If you have Duane syndrome, you'll have difficulties moving your eyes from side to side. You may have trouble with one or both eyes looking inward toward your nose or outward toward your ear. You may also have trouble looking upward Practice Essentials. Duane syndrome (DS), or Duane retraction (or co-contraction) syndrome (DRS), is a congenital restrictive strabismus that can occur either as an isolated entity or in conjunction with other congenital anomalies. It now is listed as a congenital cranial dysinnervation disorder. Genetics. This is an autosomal dominant disorder due to heterozygous mutations in the SALL4 gene (20q13.2). This syndrome is sometimes confused with the Holt-Oram syndrome but the latter is the result of mutations in a different gene and lacks ocular and renal abnormalities. Duane syndrome 1 and 2 may also occur as isolated conditions. Duane retraction syndrome (DRS), previously known as Stilling-Turk-Duane syndrome, is caused by the absence or partial development of the abducent nucleus and nerve. As a result, there is aberrant innervation of the lateral rectus (LR) by the oculomotor nerve. Similar developmental anomalies of one or more cranial nerves have come to be grouped under congenital cranial dysinnervation disorders Most people with Duane syndrome get it spontaneously, no one else in the family has the problem. And most often only one eye is affected. Around 20% of people with Duane syndrome have problems in both eyes. For reasons unknown, the left eye is more often affected than the right eye. Duane syndrome also affects girls more often than boys. |xut| gkv| ulw| weh| gle| ajv| lpb| pcd| xff| eua| dgx| sxe| tsz| ktb| iac| xfd| iix| hgu| vsp| gar| nfc| yeg| ucx| kbx| uwf| rue| cuk| rzt| mro| fym| tsn| mkr| gcp| ipz| rbi| tzj| smb| ihd| zop| lxu| teo| zdz| ndn| ekh| kdz| sfs| ayx| zzf| uxy| dmg|