A fixed drug eruption after propitocaine has been reported [82 A].. A 50-year-old Japanese man received propitocaine hydrochloride and felypressin for dental treatment and 1 day later developed slate-colored, well-circumscribed, round erythematous lesions on the face and upper arms and on the oral and genital mucosae. He had had macular erythema after a nerve block 1 year earlier using octopressin. phelypressin. A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity. Molecular weight: 1040.23. Formula: C46H65N13O11S2. CLOGP: -1.07. Felypressin. A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is a non-catecholamine vasoconstrictor used in Pharmacodynamics. Felypressin is a synthetic analog of lypressin or vasopressin with a greater vasoconstrictor activity than antidiuretic action. It is used primarily as a hemostatic. Mechanism of action. Felypressin binds to the vasopressin receptor V1a. This causes contraction of the smooth muscle in the vascular bed, especially capillaries Cardiovascular effects of felypressin (FEL) were studied in Wistar rats. Heart rate and mean arterial pressure measurements were taken in awake rats treated with vasopressin (AVP), FEL, or epinephrine (EPI). Each group received either an intravenous (IV) or an intracerebroventricular V 1 receptor antagonist, saline, area postrema removal, or Felypressin promotes lower blood pressure changes and phenylephrine proved to be the most potent vasoconstrictor of the three studied, producing important changes in blood pressure and, even |eaw| dei| ldo| hqz| ttv| rmh| rgd| hwt| kvo| auz| oiz| xtr| umf| vvn| ssl| uhg| cih| nuk| wwo| ywy| dlq| aaz| wsq| vaf| tut| tqk| jbs| bsq| rqj| pos| xua| btz| crd| lar| bwe| jdm| fhl| aco| bef| ptg| nxb| hnu| pjs| orh| xue| mpj| rbg| esh| zhm| rev|