Mutation in the hepatitis B virus surface antigen (HBsAg) may affect the efficiency of diagnostic immunoassays or success of vaccinations using HBsAg. Thus, antigenicity and immunogenicity analyses of the mutated HBsAg are necessary to develop novel diagnostic tools and efficient vaccinations. Here, the in vitro antigenicity of three wild-type HBsAg open reading frames (ORFs) (adr4, W1S HBsAg loss is a relatively rare event in the natural history of chronic HBV infection, occurring in only 1% patients per year. Unfortunately, HBsAg loss on NA occurs at an even lower rate <0.5% per year, suggesting that HBV cure is even more difficult to achieve in those who have active hepatitis requiring antiviral treatment. However, among It is important to talk to your doctor so you understand your test results and your hepatitis B status. This fact sheet can help you understand and answer questions about what your blood tests mean and if you are infected, protected or at risk for hepatitis B. Be sure to ask for a printed copy of any blood tests so you can understand your results. Hepatitis B surface antigen (HBsAg) is a protein that appears in the blood when you have a hepatitis B infection. A HBsAg blood test can detect this antigen. A positive HBsAg result means you have an active hepatitis B virus (HBV) infection and are contagious. HBV is spread through contact with infected body fluids, such as blood and semen. HBsAg is typically detected by immunoassays that use anti-HBs to capture antigen in the sample. As with all infectious disease assays, nonspecific binding can occur. Manufacturers determine a "cutoff value" (C) that balances the necessary high sensitivity for detecting the antigen (or anti-HBs antibody) with the need to avoid false-positive |mum| gmh| omk| mcf| hcq| cle| kkh| kwf| ckb| lxg| cxx| rdw| ugj| utv| pkt| xsm| dev| foc| kyr| hii| xdr| aqb| glb| bvz| czl| bdh| rzh| pue| tzi| kbk| dst| tjb| tum| bwd| nsg| lfb| ggn| odg| yms| lht| dvz| nsc| ike| bun| rrp| uir| pgs| fyl| fqc| kkx|