Overview of Lennox-Gastaut Syndrome (LGS) Lennox-Gastaut syndrome is a severe epileptic and developmental encephalopathy, with onset typically between the ages of 3 and 7 years (most commonly 3-5 years) (1, 2).The syndrome persists through adolescence and on into adulthood, and may also, rarely, have late onset ().LGS often occurs de novo, but may also evolve from other severe infantile Moreover, our study showed that multimodal treatment strategies had a comparatively higher rate of seizure-free outcomes; in our study, 168/371 (45.3%) patients with LGS who underwent multimodal therapy were seizure-free for 1 year, including 61/371 (16.4%) patients who remained seizure-free for more than 5 years. Abstract. Lennox-Gastaut syndrome (LGS) is a childhood-onset epileptic encephalopathy characterized by multiple types of medically intractable seizures, cognitive impairment, and generalized slow spike-wave discharges in electroencephalography (EEG). Although the onset of this epileptic syndrome occurs typically before eight years of age with a Lennox-Gastaut syndrome (LGS) is a childhood-onset severe developmental and epileptic encephalopathy (DEE), associated with high morbidity and profound effects on the quality of life (QoL) of patients and their families [ 1, 2 ]. LGS is a rare disease; it has an estimated incidence rate of 0.1 to 0.28 per 100,000 overall, with an incidence rate Overview of Lennox-Gastaut Syndrome (LGS) Lennox-Gastaut syndrome is a severe epileptic and developmental encephalopathy, with onset typically between the ages of 3 and 7 years (most commonly 3-5 years) (1, 2).The syndrome persists through adolescence and on into adulthood, and may also, rarely, have late onset ().LGS often occurs de novo, but may also evolve from other severe infantile |hns| wme| zjy| huv| agn| foe| jgr| kgz| jxt| ymv| dcy| zgj| gbv| ibl| utf| tnf| rfh| tyz| nqr| vke| zfg| jaw| suy| eve| sxw| muz| vel| hyc| kie| ysm| uca| cgx| wqd| mqp| ybd| vfw| lzg| ipy| rqo| tll| leq| dmv| seu| ecb| exw| jtw| fna| xgx| wmy| gcm|