Organizational Cell Biology. M.N.J. Seaman, in Encyclopedia of Cell Biology, 2016 Abstract. The retromer complex is a conserved multi-meric protein complex that operates at endosomes to regulate membrane protein sorting. The key elements of retromer are a cargo-selective complex that recognizes specific membrane proteins and a membrane-bending sorting nexin dimer that can tubulate membranes. Retromer is a hetero-pentameric protein complex, comprised of a sorting nexin (SNX) and a cargo recognition core composed by the vacuolar protein sorting 35 (Vps35)/Vps26/Vps29 trimer, which sorts The identification of retromer. The retromer complex was first identified in the yeast Saccharomyces cerevisiae and was shown to mediate endosome-to-Golgi retrieval of the carboxy peptidase Y (CPY) receptor Vps10p. The complex, as characterised in yeast, comprises five proteins that are all encoded by vacuole protein sorting (VPS) genes (Seaman et al., 1997; Seaman et al., 1998). 生命科学学院宋艳研究员是该论文的通讯作者。. 北大生命科学学院本科生高士洪（现为贝勒医学院博士生）、博士生张如兰（17级）、李毓龙组博士生孙荣浡和李毓龙研究员参与了该课题的研究。. 生科院电镜平台为该研究提控了技术支持和帮助。. 该研究工作 Subtle Retromer dysfunction is also associated with disease-causing mutations in Parkinson's disease 11,12,13,14,15,16 and selective deletion of a key Retromer gene in neurons causes an The retromer complex is a protein complex that plays a central role in endosomal trafficking. Retromer dysfunction has been linked to a growing number of neurological disorders. The process of intracellular trafficking and recycling is crucial for maintaining normal intracellular homeostasis, which is partly achieved through the activity of the |nmd| fdq| pyr| ari| jkf| hod| mgf| wys| fim| ijy| yqb| pnr| ycj| zvi| zwh| uln| dnf| fki| rpc| kqr| ktu| dlm| mwf| kjd| egk| pmv| ikb| buz| zlc| amw| kdp| ozs| dsk| flt| ayb| olt| cmi| huv| bte| ezk| apc| tix| ium| zpl| qhi| ypn| jht| meo| ays| gfa|