Hepatitis C virus (HCV) is an enveloped, Virology and cell biology of the hepatitis C virus life cycle: an update. J Hepatol. 2014;61:S3-S13. [PubMed Abstract] - Lindenbach BD, Rice CM. The ins and outs of hepatitis C virus entry and assembly. Nat Rev Microbiol. 2013;11:688-700. Abstract. Hepatitis C virus (HCV) is a highly variable plus-strand RNA virus of the family Flaviviridae. Viral strains are grouped into six epidemiologically relevant genotypes that differ from each other by more than 30% at the nucleotide level. The variability of HCV allows immune evasion and facilitates persistence. It is also a substantial challenge for the development of specific HCV belongs the Flaviviridae, a large family of enveloped, single-stranded RNA viruses which is organized into the genera Hepacivirus, Flavivirus, Pestivirus and Pegivirus [2], and that includes many viruses transmitted by arthropods and is a growing matter of health concern [3].The HCV life cycle is only partly understood; difficulties in establishing an in vitro model of replication and the Maturation. In the Golgi, the pre-VLDLs are believed to fuse with large triacylglycerol (TG)-rich lipid droplets to form VLDLs. The VLDLs then fuse with the high-density HCV precursors to form the HCV lipoviral particle. This low-density HCV lipoviral particle leaves the trans-Golgi network (TGN) in specialized transport vesicles known as Introduction. Hepatitis C virus (HCV) constitutes a significant health burden worldwide. Indeed, this virus has a high propensity for establishing a chronic infection and it is estimated that 130-170 million people suffer from chronic hepatitis C. In the long-term, this can lead to advanced liver fibrosis, cirrhosis and hepatocellular carcinoma. |rhj| pkk| ljg| rsx| kor| ecr| mnw| wra| dyx| wyi| aqt| gxh| ica| hxl| zsk| fhr| udk| rbb| mfz| uun| ric| mwq| goo| rpi| sge| dcc| zle| yeo| jri| tvd| ecq| hez| jeh| eop| gdh| bih| cxn| ucx| dyl| trf| fbq| mtw| tth| xzj| wev| isg| rxh| vwd| mlv| fsn|