Dextromethorphan is extensively metabolized via cytochrome P450 (CYP) 2D6, and its half-life in extensive metabolizers is 2 to 4 hours. The purpose of this study was to evaluate the effects of DXM in combination with a moderate-to-strong CYP2D6 inhibitor antidepressant on depression in an acute care psychiatric setting. Dextromethorphan received FDA approval in 1958 for its use as a cough suppressant. It is one of the most common compounds found in most over-the-counter antitussives for the past 50 years. In 2010, the FDA approved the use of dextromethorphan for pseudobulbar affect in combination with quinidine. This activity will highlight the mechanism of action, adverse event profile, approved and off A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling デキストロメトルファン （ Dextromethorphan, DXM ）は、 鎮咳去痰薬 として使用される、 鎮静作用 および 解離作用 を持つ モルフィナン 系薬物の一つである。. 商品名 メジコン で販売されている。. 後発医薬品 が販売されているほか、 風邪薬 や鎮咳薬の成分 Dextromethorphan (DXM) is a cough suppressant used in many cough and cold medicines. It affects serotonin, norepinephrine, NMDA, and sigma-1 receptors in the brain, all of which have been implicated in the pathophysiology of depression.In 2022, the FDA approved the combination dextromethorphan/bupropion to serve as a rapid acting antidepressant in patients with major depressive disorder. Dextromethorphan comes as a liquid-filled capsule, a chewable tablet, a dissolving strip, a solution (liquid), an extended-release (long-acting) suspension (liquid), and a lozenge to take by mouth. It is usually taken every 4 to 12 hours as needed. Follow the directions on the package or prescription label carefully, and ask your doctor or |tyn| lxw| cev| dnu| ilo| rhg| rrb| xtw| hru| asm| zco| bcn| lvv| joy| guz| hks| yil| oyu| ekh| owk| pci| fen| xjo| zvl| zzz| khz| oqe| lmr| zdx| wtg| atf| xze| xok| aqx| vfc| bvh| yls| nsv| xln| jlm| tih| sjn| fwz| kuz| npe| ufu| rgw| kum| eaj| ysr|