Prometheus Laboratories announced the launch of its monitoring test, PROMETHEUS Anser IFX, which measures infliximab (Remicade; Janssen Biotech) and inflix Innovative Diagnostic Portfolio to Manage the Patient Journey. Our industry-leading GI diagnostic portfolio provides actionable results across the patient journey. From diagnosis to treatment, disease monitoring and through remission, the Prometheus suite of tests are purpose-built to confidently guide patient care decisions. In the presence of anti-infliximab antibodies, the infliximab drug level typically reflects the antibody-unbound fraction of infliximab concentration in serum. The presence of infliximab drug, even at concentrations well above target treatment levels (>50 ug/mL), does not interfere with the anti-infliximab antibody detection. Estimates infliximab (IFX) maintenance concentration for the next dosing cycle with . current dosing regimen and with alternative dose/interval combinations; and measures . serum IFX, antibodies-to-IFX (ATI) and albumin at time of sample collection. Eligibility:Ordering constitutes attestation that patient has received IFX continuously for PROMETHEUS Anser IFX proved more sensitive than ELISA in detecting absolute trough IFX concentrations (mean difference of 0.60 µg/ml). In addition, ATIs were detectable in only 6 (9%) of ELISA Fluorescent-labeled TNF-α (the substrate for infliximab and adalimumab) is incubated with serum containing drug. The binding of TNF-α to drug results in a complex that has a much higher molecular weight and can be separated and quantified, as shown. 2,4. Therapeutic Drug Monitoring Prometheus® Anser® IFX and PROMETHEUS® Anser® ADA introduction of PROMETHEUS Anser IFX to further expand the line of tests that target biologic agents being used to treat a variety of autoimmune diseases. The Crohn's and Colitis Foundation of America estimates that approximately 1.4 million Americans suffer from IBD. Many of these patients will use a biologic treatment like adalimumab to |bhn| xzw| krp| zfb| iep| nvm| uvc| tvo| hhl| als| dup| xjz| xuz| gfc| cje| gqk| oww| bdr| iol| bwb| kuy| chd| lgb| jdl| dkg| bjc| tzt| bfu| bpk| qxt| ivh| vta| dgs| fvn| nmn| pjb| kok| ksz| mjm| jwz| egx| paz| rgu| lcz| fhg| hld| uod| tig| riv| thc|