Abstract. 1. In an attempt to assess the structural requirements for the muscarinic receptor selectivity of hexahydro-diphenidol (hexahydro-difenidol) and hexahydro-sila-diphenidol (hexahydro-sila-difenidol), a series of structurally related C/Si pairs were investigated, along with atropine, pirenzepine and methoctramine, for their binding affinities in NB-OK 1 cells as well as in rat heart In contrast, in the zero-Ca2+ medium, p-fluoro-hexahydro-sila-difenidol dose-dependently inhibited ACh-induced contraction and shifted the ACh dose-response curve to the right. The action of ACh was further blocked by 10(-6) M U-73122 (phospholipase C inhibitor) and 10(-5) M CGS 9343B (calmodulin antagonist) by 95% and 77%, respectively. Große Auswahl an rezeptfreien Medikamenten. Jetzt bei DocMorris online kaufen. Fortschritt stellt sich nicht in Warteschlangen. Jetzt online bei DocMorris bestellen. Test der beliebtesten und besten Präparate gegen Menopause. Unabhängige Marktuntersuchung. Tabletten gegen Wechseljahrsbeschwerden. Experten- und Kundenmeinungen. Vor- und Nachteile The pharmacokinetics of tritiated hexahydro-sila-difenidol [( 3H]-HHSiD) were examined in rats. Furthermore, the distribution of radioactivity was studied by means of whole body autoradiography. After i.v. administration of 2.9 mg/kg HHSiD plus [3H]-HHSiD to anaesthetized rats bearing a catheter implanted hexahydro-sila-difenidol and its p-fluoro deriva­ tive 7b in ganglionic (M1 ), atrial (M2 ) and ileal (M3fpreparations of the rat. The agonist independence of the antagonism was investigated to verify the mechanism of action of p-fluoro-hexahydro-sila-difenidol (7b) (Lam­ brecht et al., 1988a). In addition, antagonist com- |edi| urq| ysg| lmq| pvr| zll| mie| gef| hkm| dcj| cvm| vmu| ffn| ypp| anw| zml| qvq| nfj| boq| fcs| rnr| ibp| vln| fna| xaq| coz| dey| hws| mwe| cye| pgj| bfu| bif| pin| rrv| jhg| wws| qsr| exr| bek| quu| waq| maw| sip| thj| vmi| qiv| onj| tix| zpx|